Reactome: A Curated Pathway Database
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Formation of COPII vesicle

Stable Identifier
R-HSA-2130731
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Immediately after assembly in the ER nonameric (alpha beta:Ii)3 complexes egress from ER, facilitated by the presence of Ii, and enter the Golgi complex (Wolf & Ploegh 1995, Geuze 1998). Incorrectly folded or oligomerized alpha, beta and Ii chains are retained in the ER and degraded. The Sec23/24-Sar1 pre-budding complex binds to the nonameric complex and then recruits Sec13/31 outer shell, which buds off from the membrane as a coat protein complex II (COPII) vesicle to be transported to the Golgi complex (Bickford et al. 2004).

Literature References
Participants
Participant Of
Orthologous Events