Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

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Homo sapiens
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The epoxidation of arachidonic acid by cytochrome P450s (CYPs) results in the formation of unique bioactive lipid mediators termed epoxyeicosatrienoic acids (EETs). Each double bond has been shown to be susceptible to oxidation, resulting in 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. The majority of the EET biological activities are diminished by the hydrolysis to the corresponding dihydroxyeicosatrienoic acids (DHET) (Capdevila et al. 2000, Buczynski et al. 2009, Vance & Vance 2008).

Literature References
PubMed ID Title Journal Year
  Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition   2008
10681399 Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase J Lipid Res 2000
19244215 Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology J Lipid Res 2009
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