20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

Stable Identifier
R-HSA-2161745
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).

Literature References
PubMed ID Title Journal Year
2836406 The identification and formation of 20-aldehyde leukotriene B4 J Biol Chem 1988
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
20-hydroxy-leukotriene B4 omega oxidase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events