Reactome: A Curated Pathway Database

20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

Stable Identifier
R-HSA-2161745
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
20-hydroxy-leukotriene B4 omega oxidase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] 20-hydroxy-leukotriene B4 omega oxidase activity (0097258)
Orthologous Events