Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

Stable Identifier
R-HSA-2161745
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
20-hydroxy-leukotriene B4 omega oxidase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane] 20-hydroxy-leukotriene B4 omega oxidase activity (0097258)
Orthologous Events