Reactome: A Curated Pathway Database

Haptoglobin:Hemoglobin binds CD163

Stable Identifier
R-HSA-2168883
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The CD163 receptor binds the haptoglobin:hemoglobin complex (Kristiansen et al. 2001, Madsen et al. 2004, Nielsen et al. 2007). After binding, the CD163:haptoglobin:hemoglobin complex is internalized by endocytosis and is degraded in the lysosome. CD163 is found on the membranes of monocytes and macrophages.

Literature References
Participants
Participant Of
Orthologous Events