Reactome: A Curated Pathway Database

Haptoglobin:Hemoglobin binds CD163 (R-HSA-2168883)

Species Homo sapiens


The CD163 receptor binds the haptoglobin:hemoglobin complex (Kristiansen et al. 2001, Madsen et al. 2004, Nielsen et al. 2007). After binding, the CD163:haptoglobin:hemoglobin complex is internalized by endocytosis and is degraded in the lysosome. CD163 is found on the membranes of monocytes and macrophages.

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane