Reactome: A Curated Pathway Database

Haptoglobin-related Protein binds Hemoglobin (R-HSA-2168889)

Species Homo sapiens

Summation

Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region