Reactome: A Curated Pathway Database

Haptoglobin-related Protein binds Hemoglobin

Stable Identifier
R-HSA-2168889
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Formation of Trypanosome Lytic Factor1
Locations in the PathwayBrowser
Summation

Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).

Literature References
Participants
Participant Of
Orthologous Events