Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).
|16778136||Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein||Blood||2006|
|17845074||Hemoglobin is a co-factor of human trypanosome lytic factor||PLoS Pathog||2007|
|16046400||Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes||J Biol Chem||2005|
|19324878||Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein||J Biol Chem||2009|