Reactome: A Curated Pathway Database

Degradation of TGF-beta receptor complex

Stable Identifier
R-HSA-2169046
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Recruitment of SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) to the activated TGF-beta receptor complex by SMAD7 and subsequent ubiquitination of SMAD7 and/or TGFBR1 triggers degradation of SMAD7 and TGFBR1 through proteasome and lysosome-dependent routes, resulting in downregulation of signaling by TGF-beta receptors.

Literature References
Participants
Participant Of
Orthologous Events