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Degradation of TGF-beta receptor complex (R-HSA-2169046)

Species Homo sapiens

Summation

Recruitment of SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) to the activated TGF-beta receptor complex by SMAD7 and subsequent ubiquitination of SMAD7 and/or TGFBR1 triggers degradation of SMAD7 and TGFBR1 through proteasome and lysosome-dependent routes, resulting in downregulation of signaling by TGF-beta receptors.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Components of this entry
Input entries
Literature References
pubMedId Title Journal Year
11163210 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Mol Cell 2000
11278251 Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation J Biol Chem 2001
15496141 NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Biochem J 2005
Inferred Entries
Orthologous events
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