Reactome: A Curated Pathway Database

MSR1 (SCARA1, SR-A) binds ligands (R-HSA-2173778)

Species Homo sapiens

Summation

MSR1 (SCARA1, SR-A) binds oxidized and acetylated low density lipid (LDL) particles ((Brown et al. 1980), Haberland et al 1984, Gough et al. 1998, Yang et al. 2011), apolipoproteins A-I and E (human and mouse, Neyen et al. 2009), lysophosphatidylcholine from apoptotic cells (mouse, Sakai et al. 1996), phosphatidylinositol and phosphatidylserine (mouse, Nishikawa et al. 1990). MSR1 binds activated B-lymphocytes (human, Yokota et al. 1998), calreticulin and gp96 (mouse, Berwin et al. 2003). MSR1 binds bacterial products (E.coli, Neisseria meningitides, Staphylococcus aureus) (mouse, Peiser et al. 2006), Lipopolysaccharide (LPS) (mouse and bovine, Hampton et al. 1991), Lipoteichoic acid (LTA) and Gram-positive bacteria (bovine, Dunne et al. 1994), Adenovirus 5 (Haisma et al. 2009). MSR1 binds polysaccharides (carrageenan, dextran sulphate, fucoidan) (Brown et al. 1980, Krieger et al. 1992), extracellular matrix proteoglycans, biglycan and decorin (mouse, Santiago-Garcia et al. 2003). MSR1 binds extracellular matrix molecules, including denatured type I and III collagen, as well as glycated collagen IV (human and mouse and bovine, el Khoury et al. 1994, Gowen et al. 2000, Gowen et al. 2001), beta-amyloid fibrils (human and mouse, El Khoury et al. 1996), maleyl-BSA and advanced glycation end-product modified (AGE)-BSA (bovine, Brown et al. 1980, Araki et al. 1995). MSR1 binds polynucleotides (polyI, polyG) (bovine, Brown et al. 1980, Pearson et al. 1993, Mielewczyk et al. 1996), double-stranded RNA (Limmon et al. 2008, DeWitte-Orr et al. 2010). MSR1 interacts with the modified apoB-100 component of LDL (Parthasarathy et al. 1987) and with the lipid part of LDL (Terpstra et al. 1998). MSR1 is expressed most strongly on macrophages and can also be detected on endothelial cells and smooth muscle cells.

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region , plasma membrane
Literature References
pubMedId Title Journal Year
6088540 Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages J Biol Chem 1984
20360967 An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses PLoS Pathog 2010
21782039 Effect of overexpression of human SR-AI on oxLDL uptake and apoptosis in 293T cells Int Immunopharmacol 2011
9548586 A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake J Lipid Res 1998
17709607 Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA FASEB J. 2008
6255257 The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages J. Supramol. Struct. 1980
19911804 Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E Biochemistry 2009
9225214 Endocytic uptake of lysophosphatidylcholine mediated by macrophage scavenger receptor plays a major role in oxidized low density lipoprotein-induced macrophage growth J. Atheroscler. Thromb. 1996
2318890 Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages J. Biol. Chem. 1990
9511720 Scavenger receptors mediate adhesion of activated B lymphocytes Exp. Cell Res. 1998
14609958 Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells EMBO J. 2003
16926412 Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay Infect. Immun. 2006
1852209 Recognition and plasma clearance of endotoxin by scavenger receptors Nature 1991
8127896 The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid Proc. Natl. Acad. Sci. U.S.A. 1994
19227971 Scavenger receptor A: a new route for adenovirus 5 Mol. Pharm. 2009
1339697 Molecular flypaper, atherosclerosis, and host defense: structure and function of the macrophage scavenger receptor Cold Spring Harb. Symp. Quant. Biol. 1992
12488451 The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix J. Biol. Chem. 2003
8751442 Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils Nature 1996
7607209 Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction Eur. J. Biochem. 1995
8429030 Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices J. Biol. Chem. 1993
8784195 Binding studies of a triple-helical peptide model of macrophage scavenger receptor to tetraplex nucleic acids Biochemistry 1996
3467373 Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor Proc. Natl. Acad. Sci. U.S.A. 1987
9465098 Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors Proc. Natl. Acad. Sci. U.S.A. 1998
10686426 Selective adhesion of macrophages to denatured forms of type I collagen is mediated by scavenger receptors Matrix Biol. 2000