Reactome: A Curated Pathway Database

NEDD4L binds phosphorylated linker region of SMAD2/3 (R-HSA-2176491) [Homo sapiens]

Reaction
Summation

Phosphorylation of the linker region of SMAD2 and SMAD3 by CDK8 or CDK9 creates a docking site for E3-ubiquitin ligase NEDD4L.

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol Cell 2009