http://localhost/common/header.php

NEDD4L binds phosphorylated linker region of SMAD2/3 (R-HSA-2176491) [Homo sapiens]

Reaction
Summation

Phosphorylation of the linker region of SMAD2 and SMAD3 by CDK8 or CDK9 creates a docking site for E3-ubiquitin ligase NEDD4L.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Literature References
pubMedId Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol Cell 2009
Inferred Entries
Orthologous events
 
http://localhost/common/footer.php