Reactome: A Curated Pathway Database

NEDD4L ubiquitinates SMAD2/3 (R-HSA-2176502) [Homo sapiens]

Reaction
Summation

NEDD4L ubiquitinates nuclear SMAD2 and SMAD3 phosphorylated at the linker region by CDK8 or CDK9, targeting SMAD2 and SMAD3 for degradation.

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol Cell 2009