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NEDD4L ubiquitinates SMAD2/3

Stable Identifier
R-HSA-2176502
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEDD4L ubiquitinates nuclear SMAD2 and SMAD3 phosphorylated at the linker region by CDK8 or CDK9, targeting SMAD2 and SMAD3 for degradation.

Literature References
PubMed ID Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol Cell 2009
Participants
Participant Of
Orthologous Events