Reactome: A Curated Pathway Database

Degradation of SMAD2/3:SMAD4 complex (R-HSA-2176503) [Homo sapiens]

Black Box Event

NEDD4L-mediated ubiquitination of SMAD2/3 triggers degradation and ends transcriptional activity of SMAD2/3:SMAD4 complex.

Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Literature References
pubMedId Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol Cell 2009