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EGFR Transactivation by Gastrin

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).

Literature References
PubMed ID Title Journal Year
16816139 Cholecystokinin and gastrin receptors Physiol Rev 2006
20398727 EGF receptor activation by GPCRs: an universal pathway reveals different versions Mol Cell Endocrinol 2011
Participant Of
Orthologous Events
Cross References
BioModels Database