Reactome: A Curated Pathway Database
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EGFR Transactivation by Gastrin

Stable Identifier
R-HSA-2179392
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database