Reactome: A Curated Pathway Database

TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer

Stable Identifier
R-HSA-2186607
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Transcriptional repressors TGIF1 and TGIF2 bind SMAD2/3:SMAD4 heterotrimer through interaction with SMAD2 and/or SMAD3. TGIF1 and TGIF2 recruit hystone deacetylase HDAC1 to SMAD2/3:SMAD4 heterotrimer.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events