Reactome: A Curated Pathway Database

TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (R-HSA-2186607) [Homo sapiens]


Transcriptional repressors TGIF1 and TGIF2 bind SMAD2/3:SMAD4 heterotrimer through interaction with SMAD2 and/or SMAD3. TGIF1 and TGIF2 recruit hystone deacetylase HDAC1 to SMAD2/3:SMAD4 heterotrimer.

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
10199400 A Smad transcriptional corepressor Cell 1999
11427533 TGIF2 interacts with histone deacetylase 1 and represses transcription J Biol Chem 2001