Reactome: A Curated Pathway Database

MEN1 binds SMAD2/3:SMAD4 heterotrimer (R-HSA-2186643)

Species Homo sapiens


MEN1 (menin), a transcription factor tumor suppressor mutated in a familial cancer syndrome multiple endocrine neoplasia type 1, binds SMAD2/3:SMAD4 heterotrimer through interaction with SMAD3. MEN1 likely acts as a trancriptional cofactor for SMAD2/3:SMAD4 and may be involved in transcriptional regulation of some SMAD2/3:SMAD4 target genes (Kaji et al. 2001, Sowa et al. 2004, Canaff et al. 2012).

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Additional Information
Compartment nucleoplasm