Reactome: A Curated Pathway Database
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SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

Stable Identifier
R-HSA-2186741
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After phosphorylated SMAD2/3 accumulate in the nucleus in response to TGF-beta stimulation, E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007) and SMURF2 (Bonni et al. 2001) bind SKI/SKIL in complex with SMAD2/3:SMAD4 heterotrimer. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL (Levy et al. 2007). The role of SMURF2 was inferred from experiments involving human proteins only (Bonni et al. 2001).

Literature References
Participants
Participant Of
Inferred From