Ubiquitination of SKI/SKIL by RNF111/SMURF2 (R-HSA-2186747) [Homo sapiens]


E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only.

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Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 ubiquitin-protein transferase activity (0004842)
Literature References
pubMedId Title Journal Year
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation Mol Cell Biol 2007
11389444 TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation Nat Cell Biol 2001
17510063 Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling J Biol Chem 2007
Inferred Entries
Inferred From