Reactome: A Curated Pathway Database

Ubiquitination of SKI/SKIL by RNF111/SMURF2

Stable Identifier
R-HSA-2186747
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] ubiquitin-protein transferase activity (0004842)
Inferred From