Reactome: A Curated Pathway Database

Ubiquitination of SKI/SKIL by Rnf11 (R-NUL-2186755) [Homo sapiens]

Reaction
Summation

Recombinant mouse Rnf111 (Arkadia), recruited to recombinant human SKI/SKIL bound to TGF-beta-activated SMAD2/3, ubiquitinates SKI/SKIL transcriptional repressors (Levy et al. 2007, Nagano et al. 2007).

Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
p-2S-SMAD2/3:SMAD4:SKI/SKIL:Rnf11 ubiquitin-protein transferase activity (0004842)