Reactome: A Curated Pathway Database

Degradation of ubiquitinated SKI/SKIL (R-HSA-2186767) [Homo sapiens]

Black Box Event
Summation

SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano et al. 2007) or SMURF2 (Bonni et al. 2001) are degraded in a proteasome dependent way, enabling transcription of SMAD2/3:SMAD4 target genes.

Additional Information
Compartment nucleoplasm
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