Reactome: A Curated Pathway Database

SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (R-HSA-2187303) [Homo sapiens]

Black Box Event

SMAD2/3:SMAD4:SP1 complex binds SP1 and SMAD promoter elements of CDKN2B (p15-INK4B) gene and stimulates transcription of CDKN2B. CDKN2B inhibits the action of cyclin-dependent kinases CDK4 and CDK6 and may be an effector of TGF-beta induced cell cycle arrest (Feng et al. 2000).

Additional Information
Compartment nucleoplasm
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Literature References
pubMedId Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta EMBO J 2000