SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
Species Homo sapiens
SMAD2/3:SMAD4:SP1 complex binds SP1 and SMAD promoter elements of CDKN2B (p15-INK4B) gene and stimulates transcription of CDKN2B. CDKN2B inhibits the action of cyclin-dependent kinases CDK4 and CDK6 and may be an effector of TGF-beta induced cell cycle arrest (Feng et al. 2000).
Locations in the PathwayBrowser
Signal Transduction(Homo sapiens)
Gene Expression(Homo sapiens)
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