Reactome: A Curated Pathway Database

SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (R-HSA-2187303)

Species Homo sapiens

Summation

SMAD2/3:SMAD4:SP1 complex binds SP1 and SMAD promoter elements of CDKN2B (p15-INK4B) gene and stimulates transcription of CDKN2B. CDKN2B inhibits the action of cyclin-dependent kinases CDK4 and CDK6 and may be an effector of TGF-beta induced cell cycle arrest (Feng et al. 2000).

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Additional Information
Compartment nucleoplasm
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This entry is regulated by
Regulation type Name
PositiveRegulation
Literature References
pubMedId Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta EMBO J 2000