Reactome: A Curated Pathway Database

SMAD2/3:SMAD4 heterotrimer binds SP1

Stable Identifier
R-HSA-2187309
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TGF-beta (TGFB1) stimulates formation of a complex of SP1 transcription factor and SMAD2/3:SMAD4 heterotrimer. SMAD2 and SMAD4 bind to SP1 directly, through their C- and N-terminus, respectively (Feng et al. 2000).

Literature References
Participants
Participant Of
Orthologous Events