Reactome: A Curated Pathway Database

SMAD2/3:SMAD4 heterotrimer binds SP1 (R-HSA-2187309) [Homo sapiens]


TGF-beta (TGFB1) stimulates formation of a complex of SP1 transcription factor and SMAD2/3:SMAD4 heterotrimer. SMAD2 and SMAD4 bind to SP1 directly, through their C- and N-terminus, respectively (Feng et al. 2000).

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Compartment nucleoplasm
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Literature References
pubMedId Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta EMBO J 2000