Reactome: A Curated Pathway Database

SMAD2/3:SMAD4 heterotrimer binds SP1 (R-HSA-2187309) [Homo sapiens]

Reaction
Summation

TGF-beta (TGFB1) stimulates formation of a complex of SP1 transcription factor and SMAD2/3:SMAD4 heterotrimer. SMAD2 and SMAD4 bind to SP1 directly, through their C- and N-terminus, respectively (Feng et al. 2000).

Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Literature References
pubMedId Title Journal Year
11013220 Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta EMBO J 2000