Reactome: A Curated Pathway Database

PARP1 binds SMAD2/3:SMAD4 heterotrimer (R-HSA-2187330) [Homo sapiens]

Reaction
Summation

PARP1 (poly [ADP-ribose] polymerase 1) binds SMAD2/3:SMAD4 heterotrimers associated with DNA SMAD-binding elements (SBEs).

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
21095583 PARP-1 attenuates Smad-mediated transcription Mol Cell 2010