Reactome: A Curated Pathway Database

Gamma-secretase complex cleaves mNEXT2 (R-NUL-2197556)

Species Homo sapiens


By expressing mouse Notch2deltaE recombinant protein, which mimics the cleavage product of Adam10, NEXT2, in human embryonic kidney cell line HEK293, Saxena et al. demonstrated that the activity of the gamma-secretase complex was required for the release of Notch2 intracellular domain, NICD2, and the ensuing NICD2-mediated transcriptional response (Saxena et al. 2001).

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex aspartic-type endopeptidase activity (0004190)
Literature References
pubMedId Title Journal Year
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis J Biol Chem 2001