Reactome: A Curated Pathway Database

Gamma-secretase complex cleaves mNEXT2

Stable Identifier
R-NUL-2197556
Type
Reaction
Species
Homo sapiens
Compartment
Summation

By expressing mouse Notch2deltaE recombinant protein, which mimics the cleavage product of Adam10, NEXT2, in human embryonic kidney cell line HEK293, Saxena et al. demonstrated that the activity of the gamma-secretase complex was required for the release of Notch2 intracellular domain, NICD2, and the ensuing NICD2-mediated transcriptional response (Saxena et al. 2001).

Literature References
PubMed ID Title Journal Year
Participants
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] aspartic-type endopeptidase activity (0004190)
Orthologous Events