Reactome: A Curated Pathway Database

Gamma-secretase complex cleaves mNEXT2 (R-NUL-2197556) [Homo sapiens]


By expressing mouse Notch2deltaE recombinant protein, which mimics the cleavage product of Adam10, NEXT2, in human embryonic kidney cell line HEK293, Saxena et al. demonstrated that the activity of the gamma-secretase complex was required for the release of Notch2 intracellular domain, NICD2, and the ensuing NICD2-mediated transcriptional response (Saxena et al. 2001).

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex aspartic-type endopeptidase activity (0004190)
Literature References
pubMedId Title Journal Year
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis J Biol Chem 2001