Reactome: A Curated Pathway Database
THIS SITE IS USED FOR RELEASE TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Detachment of WASP/WAVE (R-HSA-2197690) [Homo sapiens]

Reaction
Summation

After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).

Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
16880808 Arp2/3 ATP hydrolysis: to branch or to debranch? Nat Cell Biol 2006
12743368 ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays Proc Natl Acad Sci U S A 2003