Reactome: A Curated Pathway Database

Detachment of WASP/WAVE (R-HSA-2197690)

Species Homo sapiens

Summation

After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
16880808 Arp2/3 ATP hydrolysis: to branch or to debranch? Nat Cell Biol 2006
12743368 ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays Proc Natl Acad Sci U S A 2003