Reactome: A Curated Pathway Database

Type XII and XIV collagens associate with type I and type II fibrils. (R-HSA-2213205) [Homo sapiens]

Black Box Event

Certain fibril-associated collagens with interrupted triple helices (FACITs) associate with the surface of collagen fibrils, where they may serve to limit fibril fusion and thereby regulate fibril diameter (Ansorge et al. 2009, Gordon & Hahn 2010). Type XII and XIV colalgens are found in association with type I (Walchli et al. 1994) and type II (Watt et al. 1992, Eyre 2002).

Additional Information
Compartment extracellular region
Literature References
pubMedId Title Journal Year
8207089 Tissue-specific expression of the fibril-associated collagens XII and XIV J Cell Sci 1994
1400327 Characterization of collagen types XII and XIV from fetal bovine cartilage J Biol Chem 1992