Reactome: A Curated Pathway Database

Collagen IX is cross-linked to the surface of collagen type II fibrils (R-HSA-2213210)

Species Homo sapiens

Summation

Certain fibril-associated collagens with interrupted triple helices (FACITs) associate with the surface of collagen fibrils, where they may serve to limit fibril fusion and thereby regulate fibril diameter (Gordon & Hahn 2010, Ricard-Blum et al. 2011). Collagen IX cross-linked to the surface of collagen type II fibrils is thought to both regulate fibril diameter and stabilize interfibrillar connections (Eyre et al. 2004). An alternative model suggests that collagen II and XI form a biological alloy (Blaschke et al. 2000).

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Compartment extracellular region
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Literature References
pubMedId Title Journal Year
14602708 Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage J Biol Chem 2004