Reactome: A Curated Pathway Database

Trafficking of nonameric complex in the endocytic pathway (R-HSA-2213235)

Species Homo sapiens

Summation

The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009).

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Additional Information
Compartment endocytic vesicle membrane , lysosomal membrane
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Literature References
pubMedId Title Journal Year
14731593 Targeting of membrane proteins to endosomes and lysosomes Trends Cell Biol 1994