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Trafficking of nonameric complex in the endocytic pathway

Stable Identifier
R-HSA-2213235
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009).

Literature References
PubMed ID Title Journal Year
14731593 Targeting of membrane proteins to endosomes and lysosomes Trends Cell Biol 1994
Participants
Participant Of
Orthologous Events