Reactome: A Curated Pathway Database

Trafficking of nonameric complex in the endocytic pathway (R-HSA-2213235) [Homo sapiens]

Black Box Event

The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009).

Additional Information
Compartment endocytic vesicle membrane , lysosomal membrane
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Literature References
pubMedId Title Journal Year
14731593 Targeting of membrane proteins to endosomes and lysosomes Trends Cell Biol 1994