Reactome: A Curated Pathway Database

NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)

Stable Identifier
R-HSA-2220982
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the nucleus, NICD1 PEST domain mutants are expected to displace the NCOR co-repressor and form a complex with RBPJ and SNW1, like wild-type NICD1 (Oka et al. 1995, Kao et al. 1998, Zhou et al. 2000, Perissi et al. 2004, Perissi et al. 2008).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]