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NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)

Stable Identifier
R-HSA-2220982
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the nucleus, NICD1 PEST domain mutants are expected to displace the NCOR co-repressor and form a complex with RBPJ and SNW1, like wild-type NICD1 (Oka et al. 1995, Kao et al. 1998, Zhou et al. 2000, Perissi et al. 2004, Perissi et al. 2008).

Participants
Participant Of
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer