Reactome: A Curated Pathway Database

NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (R-HSA-2220982) [Homo sapiens]

Reaction
Summation

In the nucleus, NICD1 PEST domain mutants are expected to displace the NCOR co-repressor and form a complex with RBPJ and SNW1, like wild-type NICD1 (Oka et al. 1995, Kao et al. 1998, Zhou et al. 2000, Perissi et al. 2004, Perissi et al. 2008).

Additional Information
Compartment nucleoplasm
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]