NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

Stable Identifier
R-HSA-2220988
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEXT1 PEST domain mutant fragments are expected to be cleaved by the gamma-secretase complex at the S3 site in a similar manner to wild-type NEXT1 (Schroeter et al. 1998, De Strooper et al. 1999, Huppert et al. 2000, Fortini 2002, Rustighi et al. 2009).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer