Reactome: A Curated Pathway Database
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NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

Stable Identifier
R-HSA-2220988
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NEXT1 PEST domain mutant fragments are expected to be cleaved by the gamma-secretase complex at the S3 site in a similar manner to wild-type NEXT1 (Schroeter et al. 1998, De Strooper et al. 1999, Huppert et al. 2000, Fortini 2002, Rustighi et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] gamma-secretase complex [plasma membrane] aspartic-type endopeptidase activity (0004190)
Disease
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]