Reactome: A Curated Pathway Database

NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (R-HSA-2220988)

Species Homo sapiens

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex aspartic-type endopeptidase activity (0004190)
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]