Reactome: A Curated Pathway Database

Hemoglobin:Haptoglobin:CD163 is endocytosed

Stable Identifier
R-HSA-2230938
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The CD163:haptoglobin:hemoglobin complex is endocytosed (Schaer et al. 2006, Kristiansen et al. 2001) by monocytes or macrophages. CD163 is constitutively endocytosed by monocytes independently of ligand binding (Schaer et al. 2006). Upon endocytosis, the receptorÔ??ligand complex enters early endosomes where haptoglobin:hemoglobin complexes are released from CD163. The receptor then recycles to the cell surface while haptoglobin:hemoglobin complexes continue through the endocytic pathway to end up in lysosomes where the protein moieties and the ligand are degraded.

Literature References
Participants
Participant Of
Orthologous Events