Reactome: A Curated Pathway Database

PDPK1 phosphorylates AKT1 E17K mutant

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

PIP2-bound AKT1 E17K mutant is constitutively phosphorylated on threonine residue T308 (Carpten et al. 2007, Landgraf et al. 2008), presumably by PIP2-bound PDPK1 (Currie et al. 1999).

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] protein serine/threonine kinase activity (0004674)
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
ovarian cancer 2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
breast cancer 1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
malignant neoplasm of large intestine 5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS