Cellular response to hypoxia

Stable Identifier
R-HSA-2262749
Type
Pathway
Species
Homo sapiens
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Summation

Oxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one aspect of cellular responses to oxygen (Semenza 2004), the role of hypoxia-inducible factor in regulating cellular transcriptional responses to changes in oxygen availability.

Literature References
PubMed ID Title Journal Year
15304631 Hydroxylation of HIF-1: oxygen sensing at the molecular level

Semenza, GL

Physiology (Bethesda) 2004
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Participant Of
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