Reactome: A Curated Pathway Database

Cellular response to hypoxia (R-HSA-2262749)

Species Homo sapiens


Oxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one aspect of cellular responses to oxygen (Semenza 2004), the role of hypoxia-inducible factor in regulating cellular transcriptional responses to changes in oxygen availability.

Locations in the PathwayBrowser
Additional Information
GO Biological Process cellular response to hypoxia (0071456)
Literature References
pubMedId Title Journal Year
15304631 Hydroxylation of HIF-1: oxygen sensing at the molecular level Physiology (Bethesda) 2004