There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Cellular response to hypoxia

Stable Identifier
R-HSA-2262749
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Oxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one aspect of cellular responses to oxygen (Semenza 2004), the role of hypoxia-inducible factor in regulating cellular transcriptional responses to changes in oxygen availability.

Literature References
PubMed ID Title Journal Year
15304631 Hydroxylation of HIF-1: oxygen sensing at the molecular level Physiology (Bethesda) 2004
Participants
Participant Of
Event Information
Orthologous Events