Reactome: A Curated Pathway Database

Collagen XI cross-links with collagen II (R-HSA-2299620) [Homo sapiens]


Type XI collagen molecules are cross-linked by lysyl oxidase-mediated bonds (Wu & Eyre 1995) primarily in a head-to-tail manner (Eyre et al. 2006). Homopolymers of type XI collagen can form in vitro (Bruckner & van der Rest 1994, Blaschke et al. 2000). Type XI collagen molecules can cross-link with type II collagen forming heterofibrils (Eyre & Wu 2004, 2005).

Additional Information
Compartment extracellular region
Literature References
pubMedId Title Journal Year
14602708 Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage J Biol Chem 2004