Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might impact on some Reactome services and we apologise for any inconvenience.

Aspirin acetylates PTGS1

Stable Identifier
R-HSA-2314678
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Aspirin (acetylsalicylate) reacts spontaneously with one subunit of PTGS1 dimer to acetylate serine residue 516. The modified enzyme is no longer capable of catalyzing the conversion of arachidonic acid to PGH2. The identity of the acetylated residue is inferred from data for the humann PTGS2 enzyme (Lecomte et al. 1994) and the ovine PGHS1 enzyme (Loll et al. 1995).

Literature References
Participants
Participant Of
Orthologous Events