Reactome: A Curated Pathway Database

Translocation of GLUT4 Vesicle translocates and docks at the plasma membrane

Stable Identifier
R-HSA-2316352
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As inferred from mouse, GLUT4 (SLC2A4) initially translocates from endosomes to insulin-responsive vesicles (IRVs, GSVs). RAB11 appears to play a role in this process. IRVs bearing GLUT4 are then translocated across the cortical actin network to the plasma membrane. Myosins 2A, 2B, 5A, and 5B contribute to translocation and are presumed to be involved in this step. Myosin 1C appears to act close to the plasma membrane and may facilitate fusion of the vesicle with the plasma membrane. RAB:GTP complexes coupled to the vesicles may interact with myosins to regulate their activity.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
microfilament motor activity of MYH2-like proteins [cytosol] MYH2-like proteins [cytosol] microfilament motor activity (0000146)
microfilament motor activity of MYH4-like proteins [cytosol] MYH4-like proteins [cytosol] microfilament motor activity (0000146)
microfilament motor activity of RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane, cytosol] RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane, cytosol] microfilament motor activity (0000146)
microfilament motor activity of p-S1652-MYO5A:F-actin [cytosol] p-S1652-MYO5A:F-actin [cytosol] microfilament motor activity (0000146)
Inferred From