GLUT4 vesicle translocates and docks at the plasma membrane

Stable Identifier
R-HSA-2316352
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As inferred from mouse, GLUT4 (SLC2A4) initially translocates from endosomes to insulin-responsive vesicles (IRVs, GSVs). RAB11 appears to play a role in this process. IRVs bearing GLUT4 are then translocated across the cortical actin network to the plasma membrane. Unconventional myosin 5A (MYO5A) interacts with RAB10 or RAB8A on the vesicle and participates in transport of the IRV. Myosin 1C appears to act close to the plasma membrane and may facilitate fusion of the vesicle with the plasma membrane. RAB:GTP complexes coupled to the vesicles may interact with myosins to regulate their activity. Non-muscle myosin IIA (MYH9) appears to interact with the SNAP23 complex to dock the IRV at the inner membrane face.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
microfilament motor activity of RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane]
Physical Entity
Activity
Title
microfilament motor activity of p-S1652-MYO5A:F-actin [cytosol]
Physical Entity
Activity
This entity is regulated by
Inferred From