Reactome: A Curated Pathway Database

PIP3 recruits PDPK1 to the membrane (R-HSA-2316429)

Species Homo sapiens


PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999).

Locations in the PathwayBrowser
Immune System(Homo sapiens)
Signal Transduction(Homo sapiens)

Additional Information
Compartment cytosol , plasma membrane
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