Reactome: A Curated Pathway Database

PIP3 recruits PDPK1 to the membrane (R-HSA-2316429) [Homo sapiens]


PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999).

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Compartment cytosol , plasma membrane
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