Reactome: A Curated Pathway Database

PIP3 recruits PDPK1 to the membrane

Stable Identifier
R-HSA-2316429
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999).

Literature References
Participants
Participant Of
Orthologous Events