Reactome: A Curated Pathway Database

DDR1 binds collagen type I, II, III, IV, V, XI fibrils

Stable Identifier
R-HSA-2327738
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Discoidin domain receptor 1 binds collagens
Locations in the PathwayBrowser
Summation

Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR1 binds several of the major fibrillar collagens (types I, II, III, and V) and the non-fibrillar collagen IV (Shrivastava et al. 1997, Vogel et al. 1997, Hou et al. 2001). DDR proteins bind collagen as dimers (Leitinger 2003, 2011). DDR1 is mostly found in epithelial cells and leukocytes. It control developmental processes and regulates cell adhesion, migration, proliferation, and remodelling of the extracellular matrix by controlling the expression and activity of matrix metalloproteinases (Leitinger & Hohenester 2007).

Literature References
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Orthologous Events