Reactome: A Curated Pathway Database

VTN binds collagens II, III and V (R-HSA-2396370) [Homo sapiens]


Vitronectin (VTN) is a major plasma glycoprotein of 75 kDa, circulating at approximately 0.2 mg/ml in humans. It interacts with collagen types I, II, III, IV, V, and VI (Gebb et al. 1986). Deglycosylation enhances VTN binding to collagen and is associated with VTN multimerization (Uchibori-Iwaki et al. 2000, Sano et al. 2007).

Additional Information
Compartment extracellular region
Literature References
pubMedId Title Journal Year
2430969 Interaction of vitronectin with collagen J. Biol. Chem. 1986