Reactome: A Curated Pathway Database

SeMet incorporation into proteins

Stable Identifier
R-HSA-2408517
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

As a first step in the incorporation of selenomethionine into proteins, tRNA(Met) is converted into selenomethionyl-tRNA(Met) (SeMet-tRNA(Met)) by methionine-tRNA ligase (MARS) component of a multisynthetase complex comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.

Literature References
Participants
Participant Of