Reactome: A Curated Pathway Database

Selenocysteine synthesis

Stable Identifier
R-HSA-2408557
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SEPSECS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

Literature References
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Participant Of
Orthologous Events