NTN4 binds laminins with gamma-1, gamma-3
Species Homo sapiens
Netrins are a family of extracellular proteins that include axonal guidance factors. They have N-terminal domains that are homologous to the LN domains of laminins. Netrin-4 (NTN4), but not other forms of netrin, bind laminin gamma-1 and gamma-3 short arms in the basement membrane, suggesting a role in regulating basement membrane formation (Schneiders et al. 2007). NTN4 has been found associated in a functional complex with laminin gamma-1 chain and integrin alpha6beta1, suggesting a role in regulation of neurogenesis in the olfactory system (Staquicini et al. 2009).
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