Reactome: A Curated Pathway Database

Laminins:Nidogens binds HSPG2

Stable Identifier
R-HSA-2426530
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Laminins:Nidogens binds Perlecan
Locations in the PathwayBrowser
Summation

The IG3 repeat in domain IV of perlecan is the principal site of interaction with nidogens, binding to the G2 domain (Mayer et al. 1998, Hopf et al. 2001). Domain V of perlecan also binds to nidogen (Brown et al. 1997). Nidogen-1 in turn binds to the laminin gamma1-subunit (Mayer et al. 1998), providing a bridge between the two proteins (Hopf et al. 1999, 2001, Kvansakul et al. 2001).

Participants
Participant Of
Inferred From