Reactome: A Curated Pathway Database

Laminins:Nidogens binds HSPG2 (R-HSA-2426530)

Species Homo sapiens

Summation

The IG3 repeat in domain IV of perlecan is the principal site of interaction with nidogens, binding to the G2 domain (Mayer et al. 1998, Hopf et al. 2001). Domain V of perlecan also binds to nidogen (Brown et al. 1997). Nidogen-1 in turn binds to the laminin gamma1-subunit (Mayer et al. 1998), providing a bridge between the two proteins (Hopf et al. 1999, 2001, Kvansakul et al. 2001).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region