Laminins:Nidogens binds HSPG2
Species Homo sapiens
The IG3 repeat in domain IV of perlecan is the principal site of interaction with nidogens, binding to the G2 domain (Mayer et al. 1998, Hopf et al. 2001). Domain V of perlecan also binds to nidogen (Brown et al. 1997). Nidogen-1 in turn binds to the laminin gamma1-subunit (Mayer et al. 1998), providing a bridge between the two proteins (Hopf et al. 1999, 2001, Kvansakul et al. 2001).
Locations in the PathwayBrowser
Extracellular matrix organization(Homo sapiens)