IGF1R signaling cascade (R-HSA-2428924) [Homo sapiens]


After autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activity (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, and Siddle et al. 2012). IRS1/2/4 can bind both PI3K (via the p85 subunit of PI3K) and the GRB2:SOS complex. PI3K activates PKB (AKT, AKT1) signaling. GRB:SOS stimulates RAS to exchange GDP for GTP leading to activation of RAF and MAPK.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
17598937 Biological & physiological aspects of action of insulin-like growth factor peptide family Indian J. Med. Res. 2007
20098959 Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain ScientificWorldJournal 2010
22649417 Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances Front Endocrinol (Lausanne) 2012
20975071 Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer J. Clin. Oncol. 2010
21042815 The IGF system Acta Diabetol 2011
18927274 The type 1 insulin-like growth factor receptor pathway Clin. Cancer Res. 2008
Inferred Entries
Orthologous events