The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling.
|17598937||Biological & physiological aspects of action of insulin-like growth factor peptide family||Indian J. Med. Res.||2007|
|20098959||Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain||ScientificWorldJournal||2010|
|22649417||Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances||Front Endocrinol (Lausanne)||2012|
|20975071||Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer||J. Clin. Oncol.||2010|
|21042815||The IGF system||Acta Diabetol||2011|
|18927274||The type 1 insulin-like growth factor receptor pathway||Clin. Cancer Res.||2008|