Reactome: A Curated Pathway Database
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IRS-related events triggered by IGF1R

Stable Identifier
R-HSA-2428928
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling.

Literature References
Participants
Participant Of
Orthologous Events