We will be undergoing a brief scheduled maintenance at Thursday Jan 18 at 10AM EST - you may experience some outages
We will be undergoing a scheduled maintenance at Thursday Jan 18 at 10AM EST
Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling.