Reactome: A Curated Pathway Database
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SHC-related events triggered by IGF1R

Stable Identifier
R-HSA-2428933
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling.

Literature References
Participants
Participant Of
Orthologous Events
Cross References