Reactome: A Curated Pathway Database

SHC-related events triggered by IGF1R (R-HSA-2428933)

Species Homo sapiens


Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000466, BIOMD0000000424