AGRN binds Beta amyloid fibril via GAG chains (R-HSA-2467665) [Homo sapiens]


Several agrin (AGRN) ligands require the presence of heparan-sulfate GAG sidechains and probably represent interactions with them. Extracellular ligands include Beta-amyloid (Donahue et al. 1999, Cotman et al. 2000). Other ligands (unconfirmed in humans) include alpha-synuclein fibrils (chicken - Liu et al. 2005), HB-GAM/pleiotropin (Dagget et al. 1996), thrombospondin and FGF2 (Cotman et al. 1999).

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region
Components of this entry
Input entries
Output entries
Literature References
pubMedId Title Journal Year
10673326 Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain Mol. Cell. Neurosci. 2000
10339611 Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma Proc. Natl. Acad. Sci. U.S.A. 1999
Inferred Entries
Orthologous events