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AGRN binds Beta amyloid fibril via GAG chains (R-HSA-2467665) [Homo sapiens]

Reaction
Summation

Several agrin (AGRN) ligands require the presence of heparan-sulfate GAG sidechains and probably represent interactions with them. Extracellular ligands include Beta-amyloid (Donahue et al. 1999, Cotman et al. 2000). Other ligands (unconfirmed in humans) include alpha-synuclein fibrils (chicken - Liu et al. 2005), HB-GAM/pleiotropin (Dagget et al. 1996), thrombospondin and FGF2 (Cotman et al. 1999).

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Additional Information
Compartment extracellular region
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Output entries
Literature References
pubMedId Title Journal Year
10673326 Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain Mol. Cell. Neurosci. 2000
10339611 Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma Proc. Natl. Acad. Sci. U.S.A. 1999
Inferred Entries
Orthologous events
 
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