Reactome: A Curated Pathway Database

Collagen type II degradation by MMP15 (R-HSA-2473594) [Homo sapiens]

Black Box Event

The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase. MMP15 is able to degrade collagen type I (Morrison & Overall 2006) and believed able to degrade types II and III (Somerville et al. 2003).

Additional Information
Compartment plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
MMP15 serine-type endopeptidase activity (0004252)