Reactome: A Curated Pathway Database
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Collagen type II degradation by MMP15

Stable Identifier
R-HSA-2473594
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase. MMP15 is able to degrade collagen type I (Morrison & Overall 2006) and believed able to degrade types II and III (Somerville et al. 2003).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of MMP15 [plasma membrane] MMP15 [plasma membrane] serine-type endopeptidase activity (0004252)
Orthologous Events