Reactome: A Curated Pathway Database

Collagen type II degradation by MMP15 (R-HSA-2473594)

Species Homo sapiens


The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase. MMP15 is able to degrade collagen type I (Morrison & Overall 2006) and believed able to degrade types II and III (Somerville et al. 2003).

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Compartment plasma membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
MMP15 serine-type endopeptidase activity (0004252)