The process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defects in the genes involved in the retinoid cycle cause degenerative retinal diseases. These defective genes are described here (for reviews see Travis et al. 2007, Palczewski 2010, Fletcher et al. 2011, den Hollander et al. 2008).
|retinal disease||5679||[Retinopathy (disorder), Retinal disorder, retina disorder]|
|21377628||Animal models of retinal disease||Prog Mol Biol Transl Sci||2011|
|18632300||Leber congenital amaurosis: genes, proteins and disease mechanisms||Prog Retin Eye Res||2008|
|20435355||Retinoids for treatment of retinal diseases||Trends Pharmacol. Sci.||2010|
|16968212||Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents||Annu. Rev. Pharmacol. Toxicol.||2007|