Reactome: A Curated Pathway Database

MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed

Stable Identifier
R-HSA-2507854
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The MSR1:ligand complex (SCARA1:ligand, SR-A:ligand) is endocytosed (Matsumoto et al. 1990, Gough et al. 1998, Peiser et al. 2000, Aguilar-Gaytan and Mas-Oliva 2003, Wang and Chandawarkar 2010, Orr et al. 2011). In the cases in which the ligands are located on bacteria or yeast cells the entire cell is phagocytosed (Aguilar-Gaytan and Mas-Oliva 2003, Wang and Chandawarkar 2010). Uptake of modified LDL by macrophages via MSR1 appears to contribute to foam cell formation during atherosclerosis (Matsumoto et al. 1990).

Literature References
Participants
Participant Of
Orthologous Events