Cytosolic iron-sulfur cluster assembly (R-HSA-2564830) [Homo sapiens]


Iron-sulfur clusters containing 4 atoms of iron and 4 atoms of sulfur (4Fe-4S clusters) are assembled in the cytosol on a heterotetrameric scaffold composed of NUBP2 and NUBP1 subunits (reviewed in Lill et al. 2012, Rouault et al. 2012, Sharma et al. 2010, Lill and Muhlenhoff 2006). The sources of iron and sulfur are uncertain but the process requires a sulfur-containing compound exported from mitochondria via ABCB7 (ABC7). Newly synthesized 4Fe-4S are transferred to apoproteins such as XPD and POLD1 via the CIA targeting complex, composed of NARFL, CIAO1, FAM96B, and MMS19.

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Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
22609301 The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism Biochim. Biophys. Acta 2012
22382365 Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease Dis Model Mech 2012
20522543 Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation J. Biol. Chem. 2010
16824008 Iron-sulfur protein biogenesis in eukaryotes: components and mechanisms Annu. Rev. Cell Dev. Biol. 2006
Inferred Entries
Inferred From
Orthologous events