FBXW7 (FBW7) is a component of the SCF (SKP1, CUL1, and F-box protein) ubiquitin ligase complex SCF-FBW7 which is involved in the degradation of NOTCH1 (Oberg et al. 2001, Wu et al. 2001, Fryer et al. 2004). Loss of function mutations in FBXW7 are frequently found in T-cell acute lymphoblastic leukemia (Akhoondi et al. 2007, Thompson et al. 2007, O'Neil et al. 2007) and are mutually exclusive with NOTCH1 PEST domain mutations (Thompson et al. 2007, O'Neil et al. 2007).
|cancer||162||[malignant tumor, malignant neoplasm, primary cancer]|
|11461910||The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog||J Biol Chem||2001|
|11585921||SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation||Mol Cell Biol||2001|
|15546612||Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover||Mol Cell||2004|
|17909001||FBXW7/hCDC4 is a general tumor suppressor in human cancer||Cancer Res.||2007|
|17646408||The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia||J Exp Med||2007|
|17646409||FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors||J Exp Med||2007|