Reactome: A Curated Pathway Database

Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642) [Homo sapiens]


Acetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then release of acetylcholine. This cycle occurs in neurons of central nervous system (CNS), peripheral, autonomic and somatic nervous system. In the CNS, the acetylcholine is released by the presynaptic neurons into the synaptic cleft where the released acetylcholine is accessible to acetylcholine receptors located on the postsynaptic neurons.

Literature References
pubMedId Title Journal Year
18029057 ATP and acetylcholine, equal brethren Neurochem Int 2008